Cell context-dependent activities of parthenolide in primary and metastatic melanoma cells
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چکیده
منابع مشابه
Comparison of c-Kit expression between primary and metastatic melanoma of skin and mucosa
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15 صفحه اولSynergy between parthenolide and arsenic trioxide in adult T-cell leukemia/lymphoma cells in vitro
Objective(s): Adult T-cell leukemia/lymphoma (ATLL) is an aggressive lymphoid malignancy with low survival rate and distinct geographical distribution. In search for novel chemotherapeutics against ATLL, we investigated the combinatorial effects of parthenolide, a sesquiterpene lactone with valuable pharmaceutical activities, and arsenic trioxide (ATO) in vitro</em...
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چکیده ندارد.
Parthenolide complements the cell death-inducing activity of doxorubicin in melanoma cells.
BACKGROUND Melanoma is characterized by high resistance to chemotherapy. The aim of this study was to investigate combined effects of doxorubicin and parthenolide on melanoma cells. MATERIALS AND METHODS Thiazolyl blue tetrazolium bromide (MTT) assay and flow cytometry were used to evaluate viability. The p53 levels and Poly-ADP ribose polymerase (PARP) cleavage were assessed by western blot....
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2010
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.2010.00749.x